Estrogen Represses whereas the Estrogen-Antagonist ICI 182780 Stimulates Placental CRH Gene Expression
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چکیده
منابع مشابه
The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling.
The mouse estrogen receptor was shown to be constantly shuttling between the nucleus and cytoplasm although under steady-state conditions it is detected predominantly in the cell nucleus in both the absence and presence of estradiol. Shuttling was demonstrated by monitoring the transfer of protein between nuclei in heterokaryons and by examining the subcellular distribution of mutant receptors....
متن کاملEstrogen represses gene expression through reconfiguring chromatin structures
Estrogen regulates over a thousand genes, with an equal number of them being induced or repressed. The distinct mechanisms underlying these dual transcriptional effects remain largely unknown. We derived comprehensive views of the transcription machineries assembled at estrogen-responsive genes through integrating multiple types of genomic data. In the absence of estrogen, the majority of genes...
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BACKGROUND The importance of estrogen in regulation of fluid absorption and sperm maturation in the rodent epididymis has been established from studies on estrogen receptor-alpha knockout mice. However, functional studies on the role of estrogen in primate epididymis have been few. The main objective of this study was therefore to extend these observations and systematically analyze the presenc...
متن کاملSelective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780.
Estrogen-stimulated cell proliferation is thought to be mediated by the induction of growth-regulatory factors. Abnormal regulation of such factors may be associated with tumorigenesis. Two such factors, vascular endothelial growth factor and c-fos, are rapidly induced in the uterus by estrogens. We show that the induction of these transcripts by 17beta-estradiol or tamoxifen is selectively blo...
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SANJAY CHANDA,1 C. LEE ROBINETTE,1,2 JOHN F. COUSE,3 AND ROBERT C. SMART1 1Molecular and Cellular Toxicology, Department of Toxicology, and 2Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27695; and 3Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of E...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 2002
ISSN: 0021-972X
DOI: 10.1210/jc.87.8.3774